Null Results in Brief IGF-I Genetic Variation and Breast Cancer: the Multiethnic Cohort
نویسندگان
چکیده
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Departments of Genetics, Medicine, and Pediatrics, Harvard Medical School; Department of Molecular Biology, Diabetes Unit, and Hematology-Oncology, Massachusetts General Hospital; Division of Genetics and Endocrinology, Children’s Hospital and Department of Pediatrics, Boston, Massachusetts; and Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii
منابع مشابه
Null Results in Brief IGF-I and IGF-II Genetic Variation and Breast Cancer Risk in Chinese Women: Results from the Shanghai Breast Cancer Study
Insulin-like growth factor (IGF)-I and IGF-II have been implicated in breast tumorigenesis due to their ability to stimulate mitogenesis and promote differentiation and their key role in mammary gland cell proliferation and survival (1-3). It has been reported that genetic variations in the gene encoding IGF-I are associated with levels of the protein and, as a consequence, may alter breast can...
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Collective evidence suggests that the insulin-like growth factor (IGF) system plays a role in prostate and breast cancer risk. IGF-binding proteins (IGFBP) are the principal regulatory molecules that modulate IGF-I bioavailability in the circulation and tissues. To examine whether inherited differences in the IGFBP1 and IGFBP3 genes influence prostate and breast cancer susceptibility, we conduc...
متن کاملIGF-I and IGF-II genetic variation and breast cancer risk in Chinese women: results from the Shanghai Breast Cancer Study.
Insulin-like growth factor (IGF)-I and IGF-II have been implicated in breast tumorigenesis due to their ability to stimulate mitogenesis and promote differentiation and their key role in mammary gland cell proliferation and survival (1-3). It has been reported that genetic variations in the gene encoding IGF-I are associated with levels of the protein and, as a consequence, may alter breast can...
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Glutathione S-transferases (GSTs) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. The human GSTs are divided into four classes: alpha, mu, pi and theta. Previous studies indicated that the absence of the Glutathione S-Transferase M1 (GSTM1) protein correlated with an increased risk of developing some types of cancers. Association between spe...
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The A-240T and I/D polymorphisms in the angiotensin I-converting enzyme (ACE) gene are markers of circulating ACE levels and have been associated with numerous cardiovascular disease outcomes. More recently, the low-activity A and I alleles at these polymorphic sites have been inversely related with breast cancer risk. We assessed the relationship between the A-240T and I/D ACE variants and bre...
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تاریخ انتشار 2006